1 / 1
|
DeCS
|
|
|
Descriptor English:
|
|
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
|
Descriptor Spanish:
|
|
Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatasas
|
Descriptor Portuguese:
|
|
Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatases
|
Synonyms English:
|
|
Phosphatases, SHIP
SHIP Phosphatases
Src Homology 2 Domain Containing Inositol Phosphatases
Src Homology 2 Domain-Containing Inositol Phosphatases
|
Tree Number:
|
|
D08.811.277.352.650.624.750
|
Definition English:
|
|
Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates. |
History Note English:
|
|
2017
|
Allowable Qualifiers English:
|
|
|
Record Number:
|
|
56477
|
Unique Identifier:
|
|
D000072183
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS
|